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Signal transduction STIM1 senses both Ca(2+) and heat
STIM proteins are ubiquitous endoplasmic reticulum Ca(2+) sensors that rapidly translocate to couple with ‘store-operated’ Orai Ca(2+) channels when luminal Ca(2+) levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601905/ https://ncbi.nlm.nih.gov/pubmed/21587254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.587 |
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