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Signal transduction STIM1 senses both Ca(2+) and heat

STIM proteins are ubiquitous endoplasmic reticulum Ca(2+) sensors that rapidly translocate to couple with ‘store-operated’ Orai Ca(2+) channels when luminal Ca(2+) levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that...

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Bibliografiske detaljer
Main Authors: Mancarella, Salvatore, Wang, Youjun, Gill, Donald L
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601905/
https://ncbi.nlm.nih.gov/pubmed/21587254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.587
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