Location and Function of STIM1 in the Activation of Ca(2+) Entry Signals

Store-operated channels (SOCs) mediate Ca(2+) entry signals in response to endoplasmic reticulum (ER) Ca(2+) depletion in most cells. STIM1 senses decreased ER luminal Ca(2+) through its EF-hand Ca(2+)-binding motif and aggregates in near-plasma membrane (PM) ER junctions to activate PM Orai1, the f...

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Detaylı Bibliyografya
Asıl Yazarlar: Hewavitharana, Thamara, Deng, Xiaoxiang, Wang, Youjun, Ritchie, Michael F., Girish, Gannareddy V., Soboloff, Jonathan, Gill, Donald L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2008
Konular:
Mechanisms of Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533777/
https://ncbi.nlm.nih.gov/pubmed/18635545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802239200
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