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pH-dependent dynamics of complex RNA macromolecules

The role of pH-dependent protonation equilibrium in modulating RNA dynamics and function is one of the key unanswered questions in RNA biology. Molecular dynamics (MD) simulations can provide insight into the mechanistic roles of protonated nucleotides, but it is only capable of modeling fixed proto...

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Detalhes bibliográficos
Main Authors: Goh, Garrett B., Knight, Jennifer L., Brooks, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601751/
https://ncbi.nlm.nih.gov/pubmed/23525495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct300942z
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