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Uncovering pH-Dependent Transient States of Proteins with Buried Ionizable Residues

[Image: see text] The role of pH in regulating biological activity is ubiquitous, and understanding pH-mediated activity has traditionally relied on analyzing static biomolecular structures of highly populated ground states solved near physiological pH. However, recent advances have shown the increa...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Goh, Garrett B., Laricheva, Elena N., Brooks, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227812/
https://ncbi.nlm.nih.gov/pubmed/24842060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5012564
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