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Residue-level resolution of alphavirus envelope protein interactions in pH-dependent fusion

Alphavirus envelope proteins, organized as trimers of E2–E1 heterodimers on the surface of the pathogenic alphavirus, mediate the low pH-triggered fusion of viral and endosomal membranes in human cells. The lack of specific treatment for alphaviral infections motivates our exploration of potential a...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Zeng, Xiancheng, Mukhopadhyay, Suchetana, Brooks, Charles L.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343099/
https://ncbi.nlm.nih.gov/pubmed/25646410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414190112
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