Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

[Image: see text] N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) NMT. These inhibitors are selective aga...

Full description

Saved in:
Bibliographic Details
Main Authors: Rackham, Mark D., Brannigan, James A., Moss, David K., Yu, Zhiyong, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601602/
https://ncbi.nlm.nih.gov/pubmed/23170970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301474t
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items