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Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
[Image: see text] N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) NMT. These inhibitors are selective aga...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2012
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601602/ https://ncbi.nlm.nih.gov/pubmed/23170970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301474t |
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