Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR and Crystallographic Studies

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is a novel target for developing new antibacterial (including anti-tuberculosis) and antimalaria drugs. 41 lipophilic phosphonates, representing a new class of DXR inhibitors, were synthesized, among which 5-phenylpyridin-2-ylmethylphosphonic aci...

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Main Authors: Deng, Lisheng, Diao, Jiasheng, Chen, Pinhong, Pujari, Venugopal, Yao, Yuan, Cheng, Gang, Crick, Dean C., Venkataram Prasad, B. V., Song, Yongcheng
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601441/
https://ncbi.nlm.nih.gov/pubmed/21561155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200363d
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