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Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling

Receptor activator of NF-κB (RANK) plays a critical role in osteoclastogenesis, an essential process for the initiation of bone remodeling to maintain healthy bone mass and structure. Although the signaling and function of RANK have been investigated extensively, much less is known about the negativ...

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Autors principals: Xia, Wen-Fang, Tang, Fu-Lei, Xiong, Lei, Xiong, Shan, Jung, Ji-Ung, Lee, Dae-Hoon, Li, Xing-Sheng, Feng, Xu, Mei, Lin, Xiong, Wen-Cheng
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601351/
https://ncbi.nlm.nih.gov/pubmed/23509071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201207154
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