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p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis
The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated. This may result from alterations in TP53 family members, including the TP53 homologue TP63. Here we demonstrate that TP...
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Autori principali: | , , , , , , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
The Rockefeller University Press
2013
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600906/ https://ncbi.nlm.nih.gov/pubmed/23420876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121439 |
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