p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated. This may result from alterations in TP53 family members, including the TP53 homologue TP63. Here we demonstrate that TP...

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Autori principali: Matin, Rubeta N., Chikh, Anissa, Law Pak Chong, Stephanie, Mesher, David, Graf, Manuela, Sanza’, Paolo, Senatore, Valentina, Scatolini, Maria, Moretti, Francesca, Leigh, Irene M., Proby, Charlotte M., Costanzo, Antonio, Chiorino, Giovanna, Cerio, Rino, Harwood, Catherine A., Bergamaschi, Daniele
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600906/
https://ncbi.nlm.nih.gov/pubmed/23420876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121439
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