iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia

iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. However, little is known about the role of iASPP under physiological conditions. Here, we report that iASPP is a cr...

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Détails bibliographiques
Auteurs principaux: Chikh, Anissa, Matin, Rubeta N H, Senatore, Valentina, Hufbauer, Martin, Lavery, Danielle, Raimondi, Claudio, Ostano, Paola, Mello-Grand, Maurizia, Ghimenti, Chiara, Bahta, Adiam, Khalaf, Sahira, Akgül, Baki, Braun, Kristin M, Chiorino, Giovanna, Philpott, Michael P, Harwood, Catherine A, Bergamaschi, Daniele
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199390/
https://ncbi.nlm.nih.gov/pubmed/21897369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.302
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