PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

Despite their nearly universal activation of mammalian target of rapamycin (mTOR) signaling, glioblastomas (GBMs) are strikingly resistant to mTOR-targeted therapy. We analyzed GBM cell lines, patient-derived tumor cell cultures, and clinical samples from patients in phase 1 clinical trials, and fin...

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Detalhes bibliográficos
Main Authors: Iwanami, Akio, Gini, Beatrice, Zanca, Ciro, Matsutani, Tomoo, Assuncao, Alvaro, Nael, Ali, Dang, Julie, Yang, Huijun, Zhu, Shaojun, Kohyama, Jun, Kitabayashi, Issay, Cavenee, Webster K., Cloughesy, Timothy F., Furnari, Frank B., Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki, Mischel, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600508/
https://ncbi.nlm.nih.gov/pubmed/23440206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217602110
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