Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis

PML is a potent tumor suppressor and proapoptotic factor and is functionally regulated by post-translational modifications such as phosphorylation, sumoylation, and ubiquitination. Histone deacetylase (HDAC) inhibitors are a promising class of targeted anticancer agents and induce apoptosis in cance...

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Bibliografiske detaljer
Main Authors: Hayakawa, Fumihiko, Abe, Akihiro, Kitabayashi, Issay, Pandolfi, Pier Paolo, Naoe, Tomoki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259823/
https://ncbi.nlm.nih.gov/pubmed/18621739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802217200
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