PPAR Activation Induces M1 Macrophage Polarization via cPLA(2)-COX-2 Inhibition, Activating ROS Production against Leishmania mexicana

Defence against Leishmania depends upon Th1 inflammatory response and, a major problem in susceptible models, is the turnoff of the leishmanicidal activity of macrophages with IL-10, IL-4, and COX-2 upregulation, as well as immunosuppressive PGE(2), all together inhibiting the respiratory burst. Per...

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Autors principals: Díaz-Gandarilla, J. A., Osorio-Trujillo, C., Hernández-Ramírez, V. I., Talamás-Rohana, P.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600276/
https://ncbi.nlm.nih.gov/pubmed/23555077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/215283
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