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PPAR Activation Induces M1 Macrophage Polarization via cPLA(2)-COX-2 Inhibition, Activating ROS Production against Leishmania mexicana
Defence against Leishmania depends upon Th1 inflammatory response and, a major problem in susceptible models, is the turnoff of the leishmanicidal activity of macrophages with IL-10, IL-4, and COX-2 upregulation, as well as immunosuppressive PGE(2), all together inhibiting the respiratory burst. Per...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600276/ https://ncbi.nlm.nih.gov/pubmed/23555077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/215283 |
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