cPLA(2) Is Protective Against COX Inhibitor–Induced Intestinal Damage

Cytosolic phospholipase A(2) (cPLA(2)) is the rate-limiting enzyme responsible for the generation of prostaglandins (PGs), which are bioactive lipids that play critical roles in maintaining gastrointestinal (GI) homeostasis. There has been a long-standing association between administration of cycloo...

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Dettagli Bibliografici
Autori principali: Montrose, David C., Kadaveru, Krishna, Ilsley, Jillian N. M., Root, Sierra H., Rajan, Thiruchanduri V., Ramesh, Manish, Nichols, Frank C., Liang, Bruce T., Sonin, Dmitry, Hand, Arthur R., Zarini, Simona, Murphy, Robert C., Belinsky, Glenn S., Nakanishi, Masako, Rosenberg, Daniel W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
Soggetti:
Molecular Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923287/
https://ncbi.nlm.nih.gov/pubmed/20562220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq184
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