cPLA(2) Is Protective Against COX Inhibitor–Induced Intestinal Damage

Cytosolic phospholipase A(2) (cPLA(2)) is the rate-limiting enzyme responsible for the generation of prostaglandins (PGs), which are bioactive lipids that play critical roles in maintaining gastrointestinal (GI) homeostasis. There has been a long-standing association between administration of cycloo...

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Bibliografiska uppgifter
Huvudupphovsmän: Montrose, David C., Kadaveru, Krishna, Ilsley, Jillian N. M., Root, Sierra H., Rajan, Thiruchanduri V., Ramesh, Manish, Nichols, Frank C., Liang, Bruce T., Sonin, Dmitry, Hand, Arthur R., Zarini, Simona, Murphy, Robert C., Belinsky, Glenn S., Nakanishi, Masako, Rosenberg, Daniel W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Molecular Toxicology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923287/
https://ncbi.nlm.nih.gov/pubmed/20562220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq184
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