CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of adenosine 5′-triphosphate (ATP), which acts as a neurotransmitter to activate afferent neural gustatory pathways(1). However, how ATP is released to fulfill this function is not fully understood....

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Hauptverfasser: Taruno, Akiyuki, Vingtdeux, Valérie, Ohmoto, Makoto, Ma, Zhongming, Dvoryanchikov, Gennady, Li, Ang, Adrien, Leslie, Zhao, Haitian, Leung, Sze, Abernethy, Maria, Koppel, Jeremy, Davies, Peter, Civan, Mortimer M., Chaudhari, Nirupa, Matsumoto, Ichiro, Hellekant, Göran, Tordoff, Michael G., Marambaud, Philippe, Foskett, J. Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600154/
https://ncbi.nlm.nih.gov/pubmed/23467090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11906
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