CALHM3 is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes

Binding of sweet, umami, and bitter tastants to G-protein coupled receptors (GPCR) in apical membranes of type II taste bud cells (TBCs) triggers action potentials that activate a voltage-gated nonselective ion channel to release ATP to gustatory nerves mediating taste perception. Although CALHM1 is...

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Publicat a:Neuron
Autors principals: Ma, Zhongming, Taruno, Akiyuki, Ohmoto, Makoto, Jyotaki, Masafumi, Lim, Jason C., Miyazaki, Hiroaki, Niisato, Naomi, Marunaka, Yoshinori, Lee, Robert J., Hoff, Henry, Payne, Riley, Demuro, Angelo, Parker, Ian, Mitchell, Claire, Henao-Mejia, Jorge, Tanis, Jessica E., Matsumoto, Ichiro, Tordoff, Michael G., Foskett, J. Kevin
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934295/
https://ncbi.nlm.nih.gov/pubmed/29681531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.03.043
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