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Humanization of Antibodies Using Heavy Chain Complementarity-determining Region 3 Grafting Coupled with in Vitro Somatic Hypermutation

A method for simultaneous humanization and affinity maturation of monoclonal antibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in vitro. To minimize the amount of murine antibody-derived antibody sequence used duri...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bowers, Peter M., Neben, Tamlyn Y., Tomlinson, Geoffery L., Dalton, Jennifer L., Altobell, Larry, Zhang, Xue, Macomber, John L., Wu, Betty F., Toobian, Rachelle M., McConnell, Audrey D., Verdino, Petra, Chau, Betty, Horlick, Robert A., King, David J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597809/
https://ncbi.nlm.nih.gov/pubmed/23355464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445502
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