Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of Antibodies

During somatic hypermutation (SHM), deamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates mutations within immunoglobulin V-regions. Nucleotide insertions and deletions (indels) have recently been shown to be critical for the evolution of antibody bindi...

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Vydáno v:J Biol Chem
Hlavní autoři: Bowers, Peter M., Verdino, Petra, Wang, Zhengyuan, da Silva Correia, Jean, Chhoa, Mark, Macondray, Griffin, Do, Minjee, Neben, Tamlyn Y., Horlick, Robert A., Stanfield, Robyn L., Wilson, Ian A., King, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246108/
https://ncbi.nlm.nih.gov/pubmed/25320089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607176
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