Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of Antibodies

During somatic hypermutation (SHM), deamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates mutations within immunoglobulin V-regions. Nucleotide insertions and deletions (indels) have recently been shown to be critical for the evolution of antibody bindi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bowers, Peter M., Verdino, Petra, Wang, Zhengyuan, da Silva Correia, Jean, Chhoa, Mark, Macondray, Griffin, Do, Minjee, Neben, Tamlyn Y., Horlick, Robert A., Stanfield, Robyn L., Wilson, Ian A., King, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246108/
https://ncbi.nlm.nih.gov/pubmed/25320089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607176
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