High Affinity Humanized Antibodies without Making Hybridomas; Immunization Paired with Mammalian Cell Display and In Vitro Somatic Hypermutation

A method has been developed for the rapid generation of high-affinity humanized antibodies from immunized animals without the need to make conventional hybridomas. Rearranged IgH D(J) regions were amplified from the spleen and lymph tissue of mice immunized with the human complement protein C5, fuse...

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Main Authors: McConnell, Audrey D., Do, Minjee, Neben, Tamlyn Y., Spasojevic, Vladimir, MacLaren, Josh, Chen, Andy P., Altobell, Laurence, Macomber, John L., Berkebile, Ashley D., Horlick, Robert A., Bowers, Peter M., King, David J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498135/
https://ncbi.nlm.nih.gov/pubmed/23166676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049458
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