Humanization of Antibodies Using Heavy Chain Complementarity-determining Region 3 Grafting Coupled with in Vitro Somatic Hypermutation

A method for simultaneous humanization and affinity maturation of monoclonal antibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in vitro. To minimize the amount of murine antibody-derived antibody sequence used duri...

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Detalhes bibliográficos
Main Authors: Bowers, Peter M., Neben, Tamlyn Y., Tomlinson, Geoffery L., Dalton, Jennifer L., Altobell, Larry, Zhang, Xue, Macomber, John L., Wu, Betty F., Toobian, Rachelle M., McConnell, Audrey D., Verdino, Petra, Chau, Betty, Horlick, Robert A., King, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597809/
https://ncbi.nlm.nih.gov/pubmed/23355464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445502
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