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piRNAs initiate an epigenetic memory of non-self RNA in the C. elegans germline

Organisms exhibit a fascinating array of gene-silencing pathways, which have evolved in part, to confront invasive nucleic acids such as transposons and viruses. A key question raised by the existence of these pathways is how do they distinguish “self” from “non-self” nucleic acids? Evidence exists...

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Hlavní autoři: Shirayama, Masaki, Seth, Meetu, Lee, Heng-Chi, Gu, Weifeng, Ishidate, Takao, Conte, Darryl, Mello, Craig C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597741/
https://ncbi.nlm.nih.gov/pubmed/22738726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.015
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