C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts

Piwi Argonautes and Piwi-interacting RNAs (piRNAs) mediate genome defense by targeting transposons. However, many piRNA species lack obvious sequence complementarity to transposons or other loci; only one C. elegans transposon is a known piRNA target. Here we show that, in mutants lacking the Piwi A...

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Bibliographic Details
Main Authors: Lee, Heng-Chi, Gu, Weifeng, Shirayama, Masaki, Youngman, Elaine, Conte, Darryl, Mello, Craig C.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410639/
https://ncbi.nlm.nih.gov/pubmed/22738724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.016
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