Identification of piRNA binding sites reveals the Argonaute regulatory landscape of the C. elegans germline

piRNAs (Piwi-interacting small RNAs) engage Piwi Argonautes to silence transposons and promote fertility in animal germlines. Genetic and computational studies have suggested that C. elegans piRNAs tolerate mismatched pairing and in principle could target every transcript. Here we employ in vivo cro...

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Publicado en:Cell
Main Authors: Shen, En-Zhi, Chen, Hao, Ozturk, Ahmet R., Tu, Shikui, Shirayama, Masaki, Tang, Wen, Ding, Yue-He, Dai, Si-Yuan, Weng, Zhiping, Mello, Craig C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905434/
https://ncbi.nlm.nih.gov/pubmed/29456082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.002
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