MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

To address how eukaryotic replication forks respond to fork stalling caused by strong non-covalent protein–DNA barriers, we engineered the controllable Fob-block system in Saccharomyces cerevisiae. This system allows us to strongly induce and control replication fork barriers (RFB) at their natural...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Bentsen, Iben B., Nielsen, Ida, Lisby, Michael, Nielsen, Helena B., Gupta, Souvik Sen, Mundbjerg, Kamilla, Andersen, Anni H., Bjergbaek, Lotte
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Genome Integrity, Repair and Replication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597703/
https://ncbi.nlm.nih.gov/pubmed/23376930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt051
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items