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Replication fork integrity and intra-S phase checkpoint suppress gene amplification
Gene amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-strand breaks (DSBs). Cells with mutant p53 lose G1/S checkpoint and are permissive to gene amplification. In this study we show that mammalian cells become proficient for spontaneous gene amplifi...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357702/ https://ncbi.nlm.nih.gov/pubmed/25672394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv084 |
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