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Complex repeat structure promotes hyper-amplification and amplicon evolution through rolling-circle replication
Inverted repeats (IRs) are abundant in genomes and frequently serve as substrates for chromosomal aberrations, including gene amplification. In the early stage of amplification, repeated cycles of chromosome breakage and rearrangement, called breakage-fusion-bridge (BFB), generate a large inverted s...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007334/ https://ncbi.nlm.nih.gov/pubmed/29718479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky275 |
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