MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

To address how eukaryotic replication forks respond to fork stalling caused by strong non-covalent protein–DNA barriers, we engineered the controllable Fob-block system in Saccharomyces cerevisiae. This system allows us to strongly induce and control replication fork barriers (RFB) at their natural...

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Detalhes bibliográficos
Main Authors: Bentsen, Iben B., Nielsen, Ida, Lisby, Michael, Nielsen, Helena B., Gupta, Souvik Sen, Mundbjerg, Kamilla, Andersen, Anni H., Bjergbaek, Lotte
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597703/
https://ncbi.nlm.nih.gov/pubmed/23376930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt051
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