MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

To address how eukaryotic replication forks respond to fork stalling caused by strong non-covalent protein–DNA barriers, we engineered the controllable Fob-block system in Saccharomyces cerevisiae. This system allows us to strongly induce and control replication fork barriers (RFB) at their natural...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Bentsen, Iben B., Nielsen, Ida, Lisby, Michael, Nielsen, Helena B., Gupta, Souvik Sen, Mundbjerg, Kamilla, Andersen, Anni H., Bjergbaek, Lotte
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2013
Aiheet:
Genome Integrity, Repair and Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597703/
https://ncbi.nlm.nih.gov/pubmed/23376930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt051
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