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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
The RecQ helicase Sgs1p forms a complex with the type 1 DNA topoisomerase Top3p that resolves double Holliday junctions resulting from Rad51-mediated exchange. We find, however, that Sgs1p functions independently of both Top3p and Rad51p to stimulate the checkpoint kinase Rad53p when replication for...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545806/ https://ncbi.nlm.nih.gov/pubmed/15616582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600511 |
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