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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance

The RecQ helicase Sgs1p forms a complex with the type 1 DNA topoisomerase Top3p that resolves double Holliday junctions resulting from Rad51-mediated exchange. We find, however, that Sgs1p functions independently of both Top3p and Rad51p to stimulate the checkpoint kinase Rad53p when replication for...

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Detalhes bibliográficos
Main Authors: Bjergbaek, Lotte, Cobb, Jennifer A, Tsai-Pflugfelder, Monica, Gasser, Susan M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545806/
https://ncbi.nlm.nih.gov/pubmed/15616582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600511
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