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Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA
In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic instability....
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| Udgivet i: | PLoS Genet |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570505/ https://ncbi.nlm.nih.gov/pubmed/28806726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006958 |
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