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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance

The RecQ helicase Sgs1p forms a complex with the type 1 DNA topoisomerase Top3p that resolves double Holliday junctions resulting from Rad51-mediated exchange. We find, however, that Sgs1p functions independently of both Top3p and Rad51p to stimulate the checkpoint kinase Rad53p when replication for...

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Publicat a:EMBO J
Autors principals: Bjergbaek, Lotte, Cobb, Jennifer A, Tsai-Pflugfelder, Monica, Gasser, Susan M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545806/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616582/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600511
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