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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
The RecQ helicase Sgs1p forms a complex with the type 1 DNA topoisomerase Top3p that resolves double Holliday junctions resulting from Rad51-mediated exchange. We find, however, that Sgs1p functions independently of both Top3p and Rad51p to stimulate the checkpoint kinase Rad53p when replication for...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545806/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600511 |
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