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An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
Rapid phosphorylation of histone variant H2AX proximal to DNA breaks is an initiating event and a hallmark of eukaryotic DNA damage responses. Three mammalian kinases are known to phosphorylate H2AX in response to DNA damage. However, the mechanism(s) for damage-localized phosphorylation remains inc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597672/ https://ncbi.nlm.nih.gov/pubmed/23325849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1478 |
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