A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA

Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes global DNA hypomethylation, especially in repetitive sequences, which comprise the large majority of methylated DNA in the...

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Библиографические подробности
Главные авторы: Shen, Li, Gao, Ge, Zhang, Ying, Zhang, He, Ye, Zhiqiang, Huang, Shichao, Huang, Jinyan, Kang, Jiuhong
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2010
Предметы:
Gene Regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952872/
https://ncbi.nlm.nih.gov/pubmed/20507910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq456
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