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A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes global DNA hypomethylation, especially in repetitive sequences, which comprise the large majority of methylated DNA in the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952872/ https://ncbi.nlm.nih.gov/pubmed/20507910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq456 |
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