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DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
CDC20 is a critical molecule in the Spindle Assembly Checkpoint (SAC). It activates the Anaphase promoting complex and helps a dividing cell to proceed towards Anaphase. CDC20 is overexpressed in many tumor cells which cause chromosomal instability. There have been limited reports on the mechanism o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677870/ https://ncbi.nlm.nih.gov/pubmed/19273532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp110 |
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