Functional DNA demethylation is accompanied by chromatin accessibility

DNA methylation inhibitors such as 5-aza-2′-deoxycytidine (5-Aza-CdR) are currently used for the treatment of myelodysplastic syndrome. Although global DNA demethylation has been observed after treatment, it is unclear to what extent demethylation induces changes in nucleosome occupancy, a key deter...

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Autors principals: Pandiyan, Kurinji, You, Jueng Soo, Yang, Xiaojing, Dai, Chao, Zhou, Xianghong J., Baylin, Stephen B., Jones, Peter A., Liang, Gangning
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Gene Regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627572/
https://ncbi.nlm.nih.gov/pubmed/23408854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt077
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