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The nitrosated bile acid DNA lesion O(6)-carboxymethylguanine is a substrate for the human DNA repair protein O(6)-methylguanine-DNA methyltransferase
The consumption of red meat is a risk factor in human colorectal cancer (CRC). One hypothesis is that red meat facilitates the nitrosation of bile acid conjugates and amino acids, which rapidly convert to DNA-damaging carcinogens. Indeed, the toxic and mutagenic DNA adduct O(6)-carboxymethylguanine...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597670/ https://ncbi.nlm.nih.gov/pubmed/23335782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1476 |
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