The nitrosated bile acid DNA lesion O(6)-carboxymethylguanine is a substrate for the human DNA repair protein O(6)-methylguanine-DNA methyltransferase

The consumption of red meat is a risk factor in human colorectal cancer (CRC). One hypothesis is that red meat facilitates the nitrosation of bile acid conjugates and amino acids, which rapidly convert to DNA-damaging carcinogens. Indeed, the toxic and mutagenic DNA adduct O(6)-carboxymethylguanine...

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Hlavní autoři: Senthong, Pattama, Millington, Christopher L., Wilkinson, Oliver J., Marriott, Andrew S., Watson, Amanda J., Reamtong, Onrapak, Eyers, Claire E., Williams, David M., Margison, Geoffrey P., Povey, Andrew C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597670/
https://ncbi.nlm.nih.gov/pubmed/23335782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1476
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