Novel synthesis of O(6)-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O(6)-methylguanine DNA methyltransferase (MGMT)

The human DNA repair protein O(6)-methylguanine DNA methyltransferase (MGMT) dealkylates mutagenic O(6)-alkylguanine lesions within DNA in an irreversible reaction which results in inactivation of the protein. MGMT also provides resistance of tumours to alkylating agents used in cancer chemotherapy...

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Detalhes bibliográficos
Main Authors: Shibata, Takayuki, Glynn, Nicola, McMurry, T. Brian H., McElhinney, R. Stanley, Margison, Geoffrey P., Williams, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435717/
https://ncbi.nlm.nih.gov/pubmed/16609128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl117
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