Tumour O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib

PURPOSE: A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). We sought to determine the dose of oral lomeguatrib, a pseudosubstrate inactivator of MGMT, required to render active protein unde...

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Autores principales: Watson, Amanda J, Sabharwal, Ami, Thorncroft, Mary, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P, Middleton, Mark R
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807621/
https://ncbi.nlm.nih.gov/pubmed/20068091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1389
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