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Tumour O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib
PURPOSE: A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). We sought to determine the dose of oral lomeguatrib, a pseudosubstrate inactivator of MGMT, required to render active protein unde...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2807621/ https://ncbi.nlm.nih.gov/pubmed/20068091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1389 |
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