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Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

While cognitive deficits are increasingly recognized as common symptoms in amyotrophic lateral sclerosis (ALS), the underlying histopathologic basis for this is not known, nor has the relevance of neuroinflammatory mechanisms and microglial activation to cognitive impairment (CI) in ALS been systema...

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Autors principals: Brettschneider, Johannes, Libon, David J., Toledo, Jon B., Xie, Sharon X., McCluskey, Leo, Elman, Lauren, Geser, Felix, Lee, Virginia M.-Y., Grossman, Murray, Trojanowski, John Q.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595560/
https://ncbi.nlm.nih.gov/pubmed/22210083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0932-x
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