Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

BACKGROUND/AIMS: We evaluated clinicopathological correlates of upper motor neuron (UMN) damage in amyotrophic lateral sclerosis (ALS), and analyzed if the presence of the C9ORF72 repeat expansion was associated with alterations in microglial inflammatory activity. METHODS: Microglial pathology was...

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Detalhes bibliográficos
Main Authors: Brettschneider, Johannes, Toledo, Jon B., Van Deerlin, Vivianna M., Elman, Lauren, McCluskey, Leo, Lee, Virginia M.-Y., Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375234/
https://ncbi.nlm.nih.gov/pubmed/22720079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039216
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