1,25-Dihydroxyvitamin D(3) Regulation of Fibroblast Growth Factor-23 Expression in Bone Cells: Evidence for Primary and Secondary Mechanisms Modulated by Leptin and Interleukin-6

Fibroblast growth factor-23 (FGF23) is a circulating hormone that acts to correct hyperphosphatemic states by inhibiting renal phosphate reabsorption and to prevent hypervitaminosis D by feedback repressing 1, 25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) biosynthesis. FGF23 gene expression in the oste...

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Main Authors: Saini, Rimpi K., Kaneko, Ichiro, Jurutka, Peter W., Forster, Ryan, Hsieh, Antony, Hsieh, Jui-Cheng, Haussler, Mark R., Whitfield, G. Kerr
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595337/
https://ncbi.nlm.nih.gov/pubmed/23263654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-012-9683-5
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