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Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts.

Treatment of intact Rat-1 fibroblasts with epidermal growth factor (EGF) leads to rapid activation of cellular ras-encoded proteins. By using the bacterial toxin streptolysin O to permeabilize these cells, it was shown that the low basal rate at which guanine nucleotides bind to, and dissociate from...

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Библиографические подробности
Главные авторы: Buday, L, Downward, J
Формат: Artigo
Язык:Inglês
Опубликовано: 1993
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC359504/
https://ncbi.nlm.nih.gov/pubmed/8441421
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