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Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis
Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits Srs2 to sites of replication where Srs2 can d...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
European Molecular Biology Organization
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594751/ https://ncbi.nlm.nih.gov/pubmed/23395907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.9 |
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