Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits Srs2 to sites of replication where Srs2 can d...

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Hauptverfasser: Burkovics, Peter, Sebesta, Marek, Sisakova, Alexandra, Plault, Nicolas, Szukacsov, Valeria, Robert, Thomas, Pinter, Lajos, Marini, Victoria, Kolesar, Peter, Haracska, Lajos, Gangloff, Serge, Krejci, Lumir
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Molecular Biology Organization 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594751/
https://ncbi.nlm.nih.gov/pubmed/23395907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.9
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