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Simultaneous Population Pharmacokinetic Modelling of Atazanavir and Ritonavir in HIV-Infected Adults and Assessment of Different Dose Reduction Strategies

OBJECTIVES: The objective of this study was to develop a simultaneous population pharmacokinetic (PK) model to describe atazanavir/ritonavir (ATV/RTV) PK (300/100 mg) and to assess the effect of RTV dose reduction on ATV PK. Simulations of ATV concentration-time profiles were performed at doses of A...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Schipani, Alessandro, Dickinson, Laura, Boffito, Marta, Austin, Rupert, Owen, Andrew, Back, David, Khoo, Saye, Davies, Gerry
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594700/
https://ncbi.nlm.nih.gov/pubmed/23011396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3182737231
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