Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies

Nonlinear mixed-effects modeling was applied to explore the relationship between lopinavir and ritonavir concentrations over 72 h following drug cessation and also to assess other lopinavir and ritonavir dosing strategies compared to the standard 400-mg–100-mg twice-daily dose. Data from 16 healthy...

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Hlavní autoři: Dickinson, Laura, Boffito, Marta, Back, David, Else, Laura, von Hentig, Nils, Davies, Geraint, Khoo, Saye, Pozniak, Anton, Moyle, Graeme, Aarons, Leon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101471/
https://ncbi.nlm.nih.gov/pubmed/21422211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00887-10
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